SuperChrom
continuous multi-column chromatography
SuperChrom
Superchrom(Super Performance Preparative Chromatography System) is a continuous chromatography process overcoming the yield-purity trade-off of single-column chromatography. Superchrom is operated fully automated with a Contichrom HPLC system. This application note shows the benefits of applying Superchrom versus single column batch chromatography for the purification of CBD. Superchrom can be operated in different ways. If the target product purity can be lower, the productivity can be further increased, meaning more product per time period can be purified.
Why Superchrom System
Superchrom is a continuous chromatography process overcoming the yield-purity trade-off of single-column chromatography. Superchrom is operated fully automated with a Contichrom HPLC system. This application note shows the benefits of applying Superchrom versus single column batch chromatography for the purification of CBD.
Superchrom can be operated in different ways. If the target product purity can be lower, the productivity can be further increased, meaning more product per time period can be purified.
SuperChrom Features
- At the same flow rate, the system operating pressure is low, which can effectively reduce the equipment load.
- The structure is flexible and changeable, which can realize the combination of various modes.
- Increase the unit production capacity of stationary phase.
- Reduce system pressure and increase product concentration.
- Three component model, three component separation, microscale component enrichment.
Superchrom Application in THC Remediation
The increase in productivity by Superchrom allows multiple manufacturing options:
- The same target amount can be produced within the same time with smaller columns
- A specified target amount can be produced in a shorter period of time with columns of the same size
- More target compound can be produced per total column volume in the same time
Superchrom Application in THC Remediation
Superchrom offers significant advantages over batch chromatography in the purification of CBD and the removal of THC, a key impurity. The advantages of it compared to single-column batch chromatography include:
- CBD yield is improved by around 80% at 100 ppm THC target impurity specifications
- The productivity is increased by a factor of 7.5 at a THC content of 1000 ppm
- The solvent consumption is reduced by 30% at a THC content of 1000 ppm
